Acivir 500 mg Injection | Acyclovir Antiviral for Herpes Infections

Introduction of Acivir 500 mg Injection

Acivir 500 mg Injection is a prescription antiviral medication containing Acyclovir, used for the treatment of severe viral infections caused by the Herpes Simplex Virus (HSV), Varicella-Zoster Virus (VZV), and other herpes group viruses. Administered via intravenous infusion, it delivers rapid antiviral action for hospitalized patients or those unable to take oral therapy.

Acyclovir works by inhibiting viral DNA synthesis, preventing the virus from multiplying in the body. Acivir is particularly useful in treating serious infections such as herpes encephalitis, disseminated herpes zoster, and HSV infections in immunocompromised patients.

✅ Active Ingredient:

• Acyclovir – 500 mg per vial (for reconstitution)
  
  

✅ Indications / Uses:

• Herpes Simplex Virus (HSV) infections, including:
  
  

• Herpes encephalitis
  
  

• Mucocutaneous HSV in immunocompromised patients
  
  

• Varicella-Zoster Virus (VZV) infections (e.g., shingles)
  
  

• Cytomegalovirus prophylaxis (off-label use)
  
  

• HSV infections in neonates
  
  

• Treatment and prevention of genital herpes recurrences
  
  

✅ Mechanism of Action:

Acyclovir is a synthetic purine nucleoside analogue that selectively inhibits the replication of herpes viral DNA by blocking the viral DNA polymerase enzyme. This action halts the replication of viral cells without affecting normal human DNA synthesis.

✅ Warnings & Precautions:

• Monitor renal function closely during treatment
  
  

• Ensure adequate hydration to prevent nephrotoxicity
  
  

• Adjust dose in renal impairment
  
  

• Use with caution in elderly patients
  
  

• May cause neurotoxicity in high doses or renal dysfunction
  
  

✅ Possible Side Effects:

Common Side Effects:

• Injection site irritation
  
  

• Headache
  
  

• Nausea
  
  

• Vomiting
  
  

• Diarrhea
  
  

Serious Side Effects:

• Renal dysfunction
  
  

• Neurotoxicity (e.g., agitation, confusion, hallucinations)
  
  

• Phlebitis
  
  

• Seizures (rare)
  
  

✅ Storage Instructions:

• Store below 25°C
  
  

• Protect from light and moisture
  
  

• Use reconstituted solution within 12 hours if stored at room temperature
  
  

Acivir 500 mg Injection offers reliable and fast-acting support against severe herpes-related viral infections. With Acyclovir as its active agent, it ensures effective control of viral replication and reduces complications associated with untreated infections.